Surgical excisions of keloids can lead to unsatisfactory outcomes with recurrence. Other symptoms may include pain, itching, and irritation. Following trauma or surgical procedures, keloids can lead to both loss of function and stigmatizing disfigurement, and present a major clinical issue. Growths of keloids neither undergo spontaneous regression nor respect original scar boundaries, differentiating them from other hypertrophic scars. A keloid is characterized by aberrant fibroblast activity with excessive formation of extracellular matrix components such as collagen. Karger AG, BaselР”Р„ keloid is a result of abnormal wound healing with pathologic proliferation of scar tissue and occurs in about 15% of the population. Overall, patients experienced symptom relief, and in some patients keloid thickness was reduced. Conclusion: In this first phase I clinical study on calcium electroporation for keloids, treatment was found to be safe with minor side effects. No serious adverse effects or recurrences were observed over a mean follow-up period of 338 days. Five out of 6 patients reported decreased pain and pruritus. A mean reduction of 11% was observed in volume size, and a mean flattening of 22% was observed (not statistically significant). Two out of 6 patients experienced a decrease in keloid thickness over 30%. Treatment was well tolerated, with all patients requesting further treatment. Results: Six patients were included in this small proof of concept study.

Treatment efficacy was evaluated clinically (size, shape, erythema), by patient self-assessment (pruritus, pain, other) and assessed histologically. Calcium was administered intralesionally (220 mM) followed by the application of eight 100-Р’Вµs pulses (400 V) using linear-array electrodes and Cliniporator (IGEA, Italy). Methods: Patients with keloids were treated with at least 1 session of calcium electroporation and followed up for 2 years. As calcium electroporation has shown limited side effects it has advantages when treating benign keloid lesions, and on this indication we performed a phase I study. Recent studies have shown promising results in the treatment of cutaneous metastases with intralesional calcium combined with electroporation (calcium electroporation). Keloids can be difficult to treat and have a high risk of recurrence. Background: Keloid scarring is a pathologic proliferation of scar tissue that often causes pruritus, pain, and disfigurement.

Calcium 10.7